FWIW my 1973-vintage Ruger Blackhawk 4-5/8" in .45 LC is my choice. Easy to carry and use, plenty of power for deer up to 50 yards (my field accuracy limit with open sights). I have used many different loads in it for deer, both cast and jacketed. Favorite bullets are the 250 XTP and 250 Lee RFN. Either one over 15 grains of BlueDot does the trick.